Novel, efficient total synthesis of natural 20(S)-camptothecin.
نویسندگان
چکیده
Enantiopure 20(S)-camptothecin has been prepared from a known hydroxypyridone through a novel approach that involves a Claisen rearrangement, an asymmetric nucleophilic ethylation, a Heck coupling and a Friedländer condensation as the key transformations.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 4 20 شماره
صفحات -
تاریخ انتشار 2006